peptidyl-arginine deiminase

peptidyl-arginine deiminase
EC Enzyme responsible for formation of protein-bound citrulline, a major amino acid in the inner root sheath and medulla of the hair follicle. Substrate is trichohyalin and postsynthetic modification of trichohylain by PAD alters its properties so that it is able to act as a rigid matrix component.

Dictionary of molecular biology. 2004.

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  • trichohyalin — Major structural protein of inner root sheath cells and medulla of hair follicle, present in small amounts in other specialised epithelia. Trichohyalin is a high molecular weight alpha helix rich protein that forms rigid structures as a result of …   Dictionary of molecular biology

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